France's proposal on the restriction of inorganic ammonium salts in cellulose wadding, prepared by ANSES, is submitted for public consultation by ECHA
Cellulose wadding is sometimes used to insulate dwellings. It may contain ammonium salts, added for their flame-retardant properties, i.e. to improve resistance to fire. However, especially under conditions of high relative humidity, these salts can lead to emissions of ammonia in the dwellings, a gas that is irritating to mucous membranes and the respiratory tract. Following reports of symptoms characteristic of the effects of this substance in some forty people, cellulose wadding containing ammonium salts was prohibited in France [1] in June 2013. France also declared that urgent action was required at European level to protect the general public from ammonia gas generated by ammonium salts used in cellulose wadding. ANSES was asked to prepare a restriction dossier under the REACh Regulation. Today, the Agency is publishing an Opinion summarising the restriction proposal submitted to the European Chemicals Agency (ECHA). On 18 June, ECHA submitted ANSES’s proposal for public consultation, on its website, for a period of six months.
Indoor air quality: ANSES proposes two guideline values for acetaldehyde
The quality of air inside buildings can be altered by various chemical or microbiological contaminants. Health effects such as respiratory diseases can also result from exposure to indoor air pollutants. The occurrence of these effects depends on the nature of the pollutants, and the intensity and duration of exposure, as well as on genetic determinants, socio-economic factors and other environmental characteristics, which also influence air quality. To address the health issue represented by indoor air quality, ANSES issued an internal request in 2004 to develop indoor air quality guideline values (IAQGs) based on health criteria. The Opinion it is publishing today therefore proposes two IAQGs for acetaldehyde, corresponding to short- and long-term exposure.
Foods fortified with phytosterols: no demonstration of an overall benefit regarding prevention of cardiovascular disease
Phytosterols are natural compounds found in plants. They can lower blood cholesterol levels by reducing its intestinal absorption through competition. EU regulations authorise claims on the labels of products fortified with phytosterols indicating that phytosterols lower blood cholesterol and on the other that lowering blood cholesterol may reduce the risk of cardiovascular disease. To address the concerns of a consumer association, ANSES is today publishing an Opinion and a Report on this issue. The study they are based on concludes that although phytosterols do indeed contribute to a reduction in blood cholesterol, there is no demonstrated benefit regarding prevention of cardiovascular disease. For people concerned about their levels of blood cholesterol, ANSES recommends personal medical surveillance covering all the levers of prevention, and reiterates its view that these products should not be used by either pregnant or breastfeeding women or by children.
ANSES publishes its assessment of the risks of emergence of antimicrobial resistance related to patterns of antibiotic use in the field of animal health
The development of antimicrobial resistance is a major concern for human and animal health. This phenomenon calls into question the effectiveness of antimicrobial drugs and may worsen the prognosis of certain infectious diseases, with major consequences for human health. With this in mind, ANSES launched an internal request to conduct an assessment of the risks of emergent antimicrobial resistance phenomena due to patterns of antibiotic use in the veterinary sphere. Its goal is to specify the most appropriate measures to implement in the field of animal health in order to establish an effective antimicrobial resistance control policy. The opinion and expert appraisal report published today provide recommendations for each sector and animal species and will supplement the initiatives currently provided for in the draft law on the future of agriculture and by the Ecoantibio 2017 plan. The recommendations include discontinuing preventive use of antibiotics, reserving latest-generation antibiotics to clearly identified and strictly regulated situations, and giving preference to narrow-spectrum antibiotics.
Perchlorate ions: ANSES's studies and recommendations
During the national measurement campaign conducted in 2011 by ANSES's Laboratory for Hydrology, perchlorate ions were detected in water intended for human consumption (WIHC) in several regions of France. These ions interfere with iodine absorption by the thyroid, one of the initial stages in thyroid hormone synthesis. At the request of the Ministry of health, ANSES has conducted a health risk assessment of the presence of perchlorate ions in WIHC and in milk formulas for infants aged 0 to 6 months, the most vulnerable population group. With regard to the calculated exposure levels, ANSES concluded that the risk of surpassing the toxicity reference value set by the Agency in 2011 cannot be excluded for certain infants. Consequently, ANSES recommends lowering perchlorate ion concentrations in infant milk formulas, and in cases where tap water is found to have perchlorate ion levels higher than 4 µg/L, it suggests that the authorities inform the public and recommend limiting tap water consumption by children under 6 months of age.
ANSES publishes its recommendations to reduce exposure to five substances which are reproductive toxicants and/or endocrine disruptors
ANSES was asked in 2009 by the Ministry of Health to identify and characterise exposure situations potentially posing a risk to health and associated with common consumer products and/or items containing certain chemicals classified as Category 2 reproductive toxicants (according to the European CLP regulation) or considered to be endocrine disruptors. Today, ANSES publishes several expert assessment reports and an opinion on five of these substances. The conclusions of the expert assessment reveal evidence of exposure situations that potentially pose a risk for embryonic or foetal development in association with exposure by pregnant women to toluene, n-hexane and cis-CTAC found in certain items or products. ANSES issues recommendations which aim to reduce the exposure of pregnant women to all five of the substances under study, in general and in the workplace in particular. It also is issuing recommendations specific to each of these substances.
Pesticide residues in foodstuffs: EFSA and ANSES publish their conclusions
Every year, the European Food Safety Authority (EFSA) assesses pesticide residue-linked food risks for the European population based on the results of a surveillance programme involving all the Member States. Today, EFSA publishes its annual report based on surveillance data from 2011. In April, ANSES also published the results of its update of the food risk indicators for pesticide residues in France. This work conducted nationally supplements and expands on the work conducted on the European level thanks to data specific to the French population. Based on this work, the French agency issues recommendations for more effective risk integration, including a reduction in the lag time between data collection and its application in assessment work, and a reinforcement of the monitoring of imported foodstuffs in order to improve their compliance with maximum residue limits.
Highlighting the toxicity of certain nanomaterials, ANSES is calling for a stronger regulatory framework
Confronted with the wide range of nanomaterials in everyday life and the many questions surrounding them, ANSES today published a review of the available literature on health and environmental issues relating to manufactured nanomaterials. This will help clarify scientific understanding and demonstrate the toxic effects of some nanomaterials on living organisms and the environment. It also emphasisesthe complexity of understanding the various situations to which humans and the environment are exposed, and the limitations of existing risk assessment methodologies. Due to this complexity, it is difficult to assess the specific risks associated with nanomaterials. Given the time it would require, the Agency recommendsthe immediate implementation of tools to improve risk management through a stronger regulatory framework at European level.
Today ANSES publishes its recommendations on dietary supplements for weight-loss containing p-synephrine
P -synephrine, a substance found in the skin of bitter oranges, is used as an ingredient in numerous so-called "weight-loss" food supplements. ANSES has received 18 reports of adverse reactions likely to be linked to consumption of food supplements containing p -synephrine. Following its assessment, ANSES considers that intake levels of p-synephrine through food supplements must remain below 20 mg/day and recommends not taking p-synéphrine with caffeine. It also recommends avoiding using products containing p -synephrine during physical exercise and discourages its use by sensitive individuals (people taking certain treatments, pregnant or breastfeeding women, children and adolescents).