List of ANSES toxicity reference values (TRVs)

The Agency entrusted TRV validation to the Expert Committee (CES) on "Health reference values ". Accordingly, toxicity reference values have already been established for the following substances (substances or mixtures).

> See our article on toxicity reference values (TRVs)

Chemical	Publication year	Sort of TRV	TRV	Internal TRV
Substances
1,2 dichloroethane (CAS 107-06-2)	2009	Long-term TRV without threshold Inhalation route	3.4 10^-3 (mg.m^-3)^-1	/
1,3-butadiène (CAS 106-99-0)	2022	Long-term TRV (with threshold) Inhalation route	2 µg.m^-3	/
1,3-butadiène (CAS 106-99-0)	2022	Long-term TRV without threshold TRV Inhalation route	7,5.10^-7 (µg.m^-3)^-1	/
2-chloroaniline (CAS 95-51-2)	2018	Short-term TRV Oral route	73 µg.kg p.c.^-1.d^-1	/
	2018	Short-term TRV Inhalation route	256 µg.m^-3
	2018	Medium-term TRV Oral route	16 µg.kg p.c.^-1.d^-1
	2018	Medium-term TRV Inhalation route	55 µg.m^-3
	2018	Long-term TRV (with threshold) Oral route	5 µg.kg p.c.^-1.d^-1
	2018	Long-term TRV (with threshold) Inhalation route	18 µg.m^-3
2-ethoxyethanol (CAS 110-80-5)	2009	Long-term TRV (with threshold) Inhalation route	0.07 mg.m^-3	/
3-chloroaniline (CAS 108-42-9)	2018	Short-term TRV Oral route	11 µg.kg p.c.^-1.d^-1	/
	2018	Short-term TRV Inhalation route	39 µg.m^-3
	2018	Medium-term TRV Oral route	5 µg.kg p.c.^-1.d^-1
	2018	Medium-term TRV Inhalation route	18 µg.m^-3
	2018	Long-term TRV (with threshold) Oral route	1 µg.kg p.c.^-1.d^-1
	2018	Long-term TRV (with threshold) Inhalation route	4 µg.m^-3
4-chloroaniline (CAS 106-47-8)	2018	Medium-term TRV Oral route	5 µg.kg p.c^.-1.d^-1	/
	2018	Medium-term TRV Inhalation route	18 µg.m^-3
	2018	Long-term TRV (with threshold) Oral route	1 µg.kg p.c.^-1.d^-1
	2018	Long-term TRV (with threshold) Inhalation route	4 µg.m^-3
4-Vinyl-1-cyclohexene (CAS 100-40-3)	2015	Long-term TRV (with threshold) Oral route	0.32 mg .kg.pc^-1.d^-1	/
	2015	Long-term TRV (with threshold) Inhalation route	2.7 mg.m^-3
	2015	Long-term TRV without threshold Oral route	1.3 10^-5 (µg.kg p.c.^-1.d^-1)^-1
	2015	Long-term TRV without threshold Inhalation route	3.8 10^-6 (µg.m^-3)^-1
Acrolein (CAS 107-02-8)	2022 (in French only)	Short-term TRV Inhalation route	6.9 µg.m^-3	/
		Medium-term TRV Inhalation route	0.44 µg.m^-3
		Long-term TRV (with threshold) Inhalation route	0.2 µg.m^-3
		Long-term TRV without threshold Inhalation route	No TRV
Ammonia (CAS 7664-41-7)	2017	Short- term TRV Inhalation route	5.9 mg.m^-3	/
		Medium-term TRV Inhalation route	0.5 mg.m^-3
		Long-term TRV (with threshold) Inhalation route	0.5 mg.m^-3
Benzene (CAS 71-43-2)	2024 (in French only)	short-term TRV Inhalation route	29 µg.m^-3	/
	2024 (in French only)	Medium-term TRV Inhalation route	19 µg.m^-3	/
	2024 (in French only)	Long-term TRV with threshold Inhalation route	9.7 µg.m^-3	/
	2024 (in French only)	Long-term TRV without threshold Inhalation route	1.6x10^-6 (µg.m-3)^-1	/
bis(2-ethylhexyl) phthalate (DEHP) (CAS 117-81-7)	2012	Long-term TRV (with threshold) Oral route	0.05 mg.kg^-1.d^-1	/
Butyl benzyl phthalate (BBP) (CAS 85-68-7)	2008	Medium-term TRV Oral route	0.5 mg.kg^-1.d^-1	/
Black carbon in ambient air	2024 (in French only)	Short-term TRV without threshold Inhalation route	1,48.10^-6(µg.m^-3)^-1	/
Black carbon in ambient air	2024 (in French only)	Long-term TRV without threshold Inhalation route	5,29.10^-2 (10-5 m-1)^-1 Pour affiner, utiliser la fonction paramétrique	/
Bromochloroacetic acid (CAS 5589-96-8)	2023 (in French only)	Long-term TRV without threshold Oral route 2023	0.16 (mg.kg^-1.d^-1)^-1	/
Bromodichloroacetic acid (CAS 71133-14-7)	2023 (in French only)	Long-term TRV without threshold Oral route 2023	0.25 (mg.kg^-1.d^-1)^-1	/
Cadmium and cadmium compounds (CAS 7440-43-9, 10108-6-2, 1306-19-0, 10124-36-4, 1306-23-6, 10325-94-7)	2017 (in French only)	Long-term TRV (with threshold) Oral route	0.35 µg.kg^-1.d^-1	0,5 µg/g creat
	2012	Long-term TRV (with threshold) Inhalation route	0.45 µg.m^-3
	2012	Long-term TRV (with threshold) Inhalation route	0.3 µg.m^-3
Carbon tetrachloride (CAS 56-23-5)	2017	Long-term TRV without threshold Inhalation route	0.11 mg.m^-3	/
Chloral hydrate (CAS 302-17-0)	2010	Long-term TRV (with threshold) Oral route	28 µg.kg^-1.d^-1	/
Chlordecone (CAS 143-50-0)	2021 (in French only)	Long-term TRV (with threshold) Oral route	0.17 µg.kg^-1.d^-1	0.40 µg/L plasma
Chloroform (CAS 67-66-3)	2008	Long-term TRV (with threshold) Inhalation route	63 µg.m^-3	/
Cylindrospermopsin (CAS 143 545-90-8)	2019	Medium-term TRV Oral route	0.14 µg.kg^-1.d^-1	/
Decamethylcyclopentasiloxane (D5) (CAS 541-02-6)	2017	Long-term TRV (with threshold) Inhalation route	6..4 mg.m^-3	/
Dibromoacetic acid (CAS 631-64-1)	2010	Long-term TRV (with threshold) Oral route	30 µg.kg^-1.d^-1	/
Dibromoacetic acid (CAS 631-64-1)	2023 (in French only)	Long-term TRV without threshold Oral route	0.048 (mg.kg^-1.d^-1)^-1
Dibromochloroacetic acid (CAS 5278-95-5)	2023 (in French only)	Long-term TRV Oral route	No TRV	/
Dibutyl phthalate (DBP) (CAS 84-74-2)	2008	Medium-term TRV Oral route	0.002 mg.kg^-1.d^-1	/
Diisobutylene (DIB) (CAS 25167-70-8)	2015	Long-term TRV (with threshold) Oral route	0.8 mg.kg pc^-1.d^-1	/
Diisobutylene (DIB) (CAS 25167-70-8)	2015	Long-term TRV (with threshold) Inhalation route	3 mg.m^-3	/
Diisopropyl ether (DIPE) (CAS 108-20-3)	2015	Long-term TRV (with threshold) Oral route	4 mg.kg pc^-1.d^-1	/
	2015	Long-term TRV (with threshold) Inhalation route	14,5 mg.m^-3
	2015	Developmental TRV Oral route	2 mg.kg pc^-1.d^-1
	2015	Developmental TRV Inhalation route	7.2 mg.m^-3
	2015	Long-term TRV without threshold Oral route	7.8.10^-6 (µg.kg p.c.^-1.d^-1)^-1
	2015	Long-term TRV without threshold Inhalation route	2.2.10^-6 (µg.m^-3)^-1
Dichloroacetic acid (CAS 79-43-6)	2009	Short- term TRV Oral route	260 µg.kg^-1.d^-1	/
	2009	Long-term TRV (with threshold) Oral route	840 µg.kg^-1.d^-1	/
	2023 (in French only)	Long-term TRV without threshold Oral route	0,048 (mg.kg^-1.d^-1)^-1	/
Diisobutyl phthalate (DIBP) (CAS 84-69-5)	2017	Short-term TRV (reprotoxic) Oral route	0.002 mg.kg^-1.d^-1	/
Diisooctyl phthalate (DIOP) (CAS 27554-26-3)	2017	Short-term TRV (reprotoxic) Oral route	0.004 mg.kg^-1.d^-1	/
Dinitrotoluene – isomer 2,4 (CAS 121-14-2)	2024 (in French only)	Long-term TRV (with threshold) Oral route	0,003 mg.kg pc⁻¹.d⁻¹	/
Dinitrotoluene – isomer 2,4 (CAS 121-14-2)	2024 (in French only)	Long-term TRV (without threshold) Oral route	0,13 (mg.kg pc⁻¹.d⁻¹)⁻¹	/
Dinitrotoluene – isomer 2,6 (CAS 606-20-2)	2024 (in French only)	Long-term TRV (with threshold) Oral route	0,003 mg.kg pc⁻¹.d⁻¹	/
Dinitrotoluene – isomer 2,6 (CAS 606-20-2)	2024 (in French only)	Long-term TRV (without threshold) Oral route	0,79 (mg.kg pc⁻¹.d⁻¹)⁻¹	/
Dimethyl phthalate (CAS 131-22-3)	2015 (in French only)		No TRV	/
Di-n-octyl phthalate (DnOP) (CAS 117-84-0)	2017		No TRV	/
Ethyl acetate (CAS 141-78-9)	2015	Long-term TRV (with threshold) Inhalation route	6.4 mg.m^-3	/
Ethylbenzene (CAS 100-41-1)	2016	Short-term TRV Inhalation route	22 mg.m^-3	/
		Medium-term TRV Inhalation route	4.3 mg.m^-3
		Long-term TRV (with threshold) Inhalation route	1.5 mg.m^-3
Formaldehyde (CAS 50-00-0)	2017	Short-term TRV Inhalation route	123 µg.m^-3	/
Formaldehyde (CAS 50-00-0)	2017	Long-term TRV (with threshold) Inhalation route	123 µg.m^-3	/
Lead (CAS 7439-92-1)	2012	Blood lead level		15 µg.L-1 blood
Linuron (CAS 330-55-2)	2008	Medium-term TRV Oral route	0.05 mg.kg^-1.d^-1	/
Methyl methacrylate (CAS 80-62-6)	2017	Long-term TRV (with threshold) Inhalation route	0.7 mg.m^-3	/
Microcystin-LR (CAS 101043-37-02)	2019	Medium-term TRV Oral route	1 ng.kg^-1.d^-1	/
Monochloroacetic acid (CAS 79-11-8)	2023 (in French only)	Long-term TRV (with threshold) Oral route	10 µg.kg^-1.d^-1	/
n-butyl acetate (CAS 123-86-4)	2017	Long-term TRV (with threshold) Inhalation route	2 mg.m^-3	/
N-hexane (CAS 110-54-3)	2013	Long-term TRV (with threshold) Inhalation route	3 mg.m^-3	/
m-nitrochlorobenzene (CAS 121-73-3)	2009	Long-term TRV without threshold Inhalation and oral route	No TRV	/
N-nitrosomorpholine (CAS 59-89-2)	2012 (in French only)	Long-term TRV without threshold Oral route	4 (mg.kg p.c.^-1.d^-1)^-1	/
Naphthalene (CAS 91-20-3)	2013	Long-term TRV (with threshold) Inhalation route	37 µg.m^-3	/
Naphthalene (CAS 91-20-3)	2013	Long-term TRV without threshold Inhalation route	5.6.10^-3 (mg.m^-3)^-1	/
o- nitrochlorobenzene (CAS 88-73-3)	2009	Long-term route (with threshold) Oral route	80 µg.kg^-1.d^-1	/
o- nitrochlorobenzene (CAS 88-73-3)	2009	Long-term TRV without threshold Oral route	6.10^-5(µg.kg^-1.d^-1)^-1	/
p-nitrochlorobenzene (CAS 100-00-5)	2009	Long-term TRV (with threshold) Oral route	34 µg.kg^-1.d^-1	/
p-nitrochlorobenzene (CAS 100-00-5)	2009	Long-term TRV without threshold Oral route	5.10^-5 (µg.kg-1.d^-1)^-1	/
Nonylphenol - branched (CAS 90481-04-2 84852-15-3)	2009	Medium-term TRV Oral route	0.03 mg.kg^-1.d^-1	/
Nonylphenol - linear (CAS 25154-52-3 / 104-40-5)	2009	Medium-term TRV Oral route	0.03 mg.kg^-1.d^-1	/
Octamethylcyclotetrasiloxane (CAS S 556-67-2)	2017	Long-term TRV (with threshold) Inhalation route	183 mg.m^-3	/
Palytoxin (CAS 77734-91-9)	2023 (in French only)	Short-term TRV Oral route	0.08 µg.kg-¹.d^-1	/
Palytoxin (CAS 77734-91-9)	2023 (in French only)	No short- and medium-term TRV Respiratory and dermal route		/
Particulate matter in ambient air PM2.5	2024 (in French only)	Short-term TRV without threshold Inhalation route	For [PM2,5] ≤ 10 µg.m^-3 : 1,65.10^-7 (µg.m^-3)^-1 For [PM2,5] > 10 µg.m^-3: 7,69.10^-9 (µg.m^-3)^-1 + 1,56.10^-6	/
Particulate matter in ambient air PM2.5	2023 (in French only)	Long-term TRV without threshold Inhalation route	1.28.10^-2 (µg.m^-3)^-1 To refine, use the parametric function	/
Particulate matter in ambient air PM10	2024	Short-term TRV without threshold Inhalation route	For [PM10] ≤ 20 µg.m^-3: 7,34.10^-8 (µg.m^-3)^-1 For [PM10] > 20 µg.m^-3 : 7,71.10^-9 (µg.m^-3)^-1 + 1,33.10^-6
Particulate matter in ambient air PM10	2023 (in French only)	Long-term TRV without threshold Inhalation route	Conversion of PM10 exposure concentration to PM2.5 concentration, then use the long-term TRV of PM2.5	/
Perchlorates ions (CAS 14797-73-0)	2022	Long-term TRV (with threshold) Oral route	1.5 µg.kg^-1.d^-1	/
Perchloroethylene (CAS 127-18-4)	2018	Short-term TRV Inhalation route	1.38 mg.m^-3	/
		Medium-term TRV Inhalation route	0.4 mg.m^-3
		Long-term TRV (with threshold) Inhalation route	0.4 mg.m^-3
		Long-term TRV without threshold Inhalation route	2.6.10^-7 (µg.m^-3)^-1
Perfluorobutanesulfonic acid (CAS 375-73-5)	2017	Long-term TRV (with threshold) Oral route	0.08 mg.kg^-1.d^-1	/
Perfluorohexanoic acid (CAS 307-24-4)	2017	Long-term TRV (with threshold) Oral route	0.32 mg.kg^-1.d^-1	/
Pinnatoxine G (CAS 1312711-74-2)	2019 (in French only)	Provisional acute TRV Oral route	0.13 µg.kg pc^-1.j^-1	/
Saxitoxin (CAS 35523-89-8)	2020	Acute TRV Oral route	0.1 µg.kg^-1.j^-1	/
Sec butyl éther (CAS 6863-58-7)	2015	No TRV		/
Tert-butanol (TBA) (CAS 75-65-0)	2015	Reprotoxic TRV Oral route	1.9 mg.kg pc^-1.d^-1	/
	2015	Long-term TRV (with threshold) Oral route	0.6 mg.kg pc^-1.d^-1
	2015	Long-term TRV (with threshold) Inhalation route	2.1 mg.m^-3
Titanium dioxide under nanoform (P25) (CAS 13463-67-7)	2019	Long-term TRV (with threshold) Inhalation route	0.12 µg.m^-3	/
Tribromoacetic acid	2023 (in French only)	Long-term TRV (with threshold) Oral route	No TRV	/
Trichloroacetic acid (CAS 76-03-9)	2009	Short-term TRV Oral route	300 µg.kg^-1.d^-1	/
Trichloroacetic acid (CAS 76-03-9)	2023 (in French only)	Long-term TRV (with threshold) Oral route	20 µg.kg^-1.d^-1	/
Trichloroethylene (CAS 79-01-6)	2018	Short-term TRV Inhalation route	No TRV	/
	2018	Medium-term TRV Inhalation route	3.2mg.m^-3
	2018	Long-term TRV (with threshold) Inhalation route	3.2 mg.m^-3
	2018	Long-term TRV without threshold Inhalation route	10-6 (µg.m^-3)^-1
Toluene (CAS 108-88-3)	2017	Short-term TRV Inhalation route	21 mg.m^-3	/
Toluene (CAS 108-88-3)	2017	Long-term TRV (with threshold) Inhalation route	19 mg.m^-3	/
Vinyl chloride (CAS 75-01-4)	2012	Long-term TRV without threshold Oral route	0.625 (mg.kg^-1.d^-1)^-1	/
Vinyl chloride (CAS 75-01-4)	2012	Long-term TRV without threshold Inhalation route	0.0038 (mg.m^-3)^-1	/
Sodium valproate (CAS 1069-66-5)	2021 (in French only)	Reprotoxic TRV Oral route	0.08 mg.kg^-1.d^-1	/
		Reprotoxic TRV Inhalation route	0.26 mg.m^-3
		Long-term TRV (with threshold) Oral route	0.03 mg.kg^-1.d^-1
		Long-term TRV (with threshold) Inhalation route	0.12 mg.m^-3
Xylènes (xylène technique CAS n°1330-20-7 méta-xylène CAS n°108-38-3 ortho-xylène CAS n°95-47-6 para-xylène CAS n°106-42-3)	2020	Short-term TRV Inhalation route	8.7 mg.m^-3	/
	2020	Long-term TRV (with threshold) Inhalation route	0.1 mg.m^-3	/
Mixtures
BTEX mixture (benzene, toluene, ethylbenzene, xylenes)	2022 (in French only)	Toxicological value based on the common effect considered for the different chemicals of the mixture (MTV)	Benzene : MTVneurotoxicy = 0.065 mg.m^-3 Toluene : MTVneurotoxicy = 19 mg.m-3 Ethylbenzene : MTVneurotoxicy = 6 mg.m^-3 Xylenes : MTVneurotoxicy = 0.1 mg.m^-3

Update date: Decembe 2024

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